Patriots vs. 49ers game day roster: More changes along the O-line, replacing Anfernee Jennings, and more

Coming off a mini-bye, the New England Patriots will play their third road game in four weeks on Sunday afternoon. Traveling to the Bay Area for the first time in eight years, they will take on the San Francisco 49ers in a battle of 1-2 teams.

Their game day roster for the contest looks as follows:

Patriots game day rosterQuarterback (2): Jacoby Brissett (7), Drake Maye (10)

Running back (3): Rhamondre Stevenson (38), Antonio Gibson (4), JaMycal Hasty (39 | KR)

Wide receiver (6): DeMario Douglas (3), Ja'Lynn Polk (1), K.J. Osborn (2), Tyquan Thornton (11), Javon Baker (6), Kayshon Boutte (9)

Tight end (3): Hunter Henry (85), Austin Hooper (81), Mitchell Wilcox (86)

Offensive tackle (4): Caedan Wallace (70 | LT), Michael Onwenu (71 | RT), Zachary Thomas (72), Demontrey Jacobs (75)

Interior offensive line (4): Sidy Sow (62 | LG), David Andrews (60 | C), Layden Robinson (63 | RG), Nick Leverett (51)

Interior defensive line (7): Davon Godchaux (92), Keion White (99), Deatrich Wise Jr. (91), Daniel Ekuale (95), Jeremiah Pharms Jr. (98), Eric Johnson (96), Trysten Hill (97)

Defensive edge (1): Joshua Uche (55)

Linebacker (4): Jahlani Tavai (48), Raekwon McMillan (50), Christian Elliss (53), Curtis Jacobs (52)

Cornerback (6): Christian Gonzalez (0), Jonathan Jones (31), Marcus Jones (25 | PR), Marco Wilson (22), Marcellas Dial Jr. (27), Isaiah Bolden (29)

Safety (5): Kyle Dugger (23), Jabrill Peppers (5), Jaylinn Hawkins (21), Brenden Schooler (41), Dell Pettus (24)

Specialists (3): Joey Slye (13 | K), Bryce Baringer (17 | P | H), Joe Cardona (49 | LS)

The Patriots offensive line will field its fourth different starting lineup in as many weeks on Sunday.

While the right side of the line has been quite stable, the left remains a major question mark. Starting tackle Vederian Lowe is out once again, with Caedan Wallace replacing him for a second straight week. At left guard, New England will finally reinsert starter Sidy Sow who missed the first four games with an ankle injury suffered in preseason.

Questions also exist along the defensive edge. On paper, Joshua Uche is the only player available — meaning that the team will have to get creative to replace Anfernee Jennings (inactive/shoulder) and Oshane Ximines (injured reserve/knee). There are several likely candidates available, though.

New England might turn to versatile defensive linemen Keion White and Deatrich Wise Jr. to kick out more often against a talented 49ers ground game. In addition, off-ball linebackers Jahlani Tavai and Raekwon McMillan have shown the ability to play on the line as well.

Additionally, the Patriots again dressed six wide receivers. Cornerback Isaiah Bolden, meanwhile, will make his season debut one day after getting signed from the practice squad to the 53-man roster.

Patriots reservesInactives (6): TE Jaheim Bell, ED Anfernee Jennings, G Michael Jordan, DE Jamree Kromah, OT Vederian Lowe, QB Joe Milton III (emergency QB)

Practice squad (13): OL Liam Fornadel, LB Joe Giles-Harris, RB Kevin Harris, C Bryan Hudson, CB D.J. James, RB Terrell Jennings, OT Caleb Jones, WR Matt Landers, ED Ochaun Mathis, S Mark Perry, DT Jacquelin Roy, OT Jalen McKenzie, WR John Jiles

Practice squad international (1): ED Jotham Russell

Reserve/left squad (1): OT Chukwuma Okorafor

Reserve/NFI (1): DT Christian Barmore

Reserve/PUP (3): WR Kendrick Bourne, G Cole Strange, LB Sione Takitaki

Injured reserve (7): OL Jake Andrews, CB Alex Austin, LB Ja'Whaun Bentley, WR JaQuae Jackson, S/LB Marte Mapu (IR-R), DT Armon Watts, ED Oshane Ximines

New England's list of reserves features few surprises. The aforementioned Anfernee Jennings is the biggest name among the inactives.

The Patriots' Week 4 game against the 49ers will be kicked off at 4:05 p.m. ET at Levi's Stadium in Santa Clara.