Pro Picks: Six teams are road favorites and two more are slight underdogs in Week 10

Pro Picks is a weekly column where AP Pro Football Writer Rob Maaddi shares his picks for upcoming games. For all previous Pro Picks, head here .

— 105.1 vs. 67.2 passer rating home/away. The Bears have won eight straight games overall at Soldier Field, including three this season. Maye has shown playmaking ability that should give New England fans hope.
BEARS: 24-16

Buffalo (7-2) at Indianapolis (4-5)

Line: Bills minus 4

Josh Allen is playing outstanding, mistake-free ball and the Bills are running away with the AFC East. They've beat softer teams on their schedule but have tougher challenges ahead, including this one against Joe Flacco and the Colts on the road. All nine of Indianapolis' games this season have been decided by one possession. The Colts are 6-1 against the spread in their past seven games overall and 6-0 ATS in their past six games vs. AFC opponents.

BILLS: 26-23

Denver (5-4) at Kansas City (8-0)

Line: Chiefs minus 8 1/2

The unbeaten two-time defending Super Bowl champion Chiefs are starting to hit their stride on offense as Patrick Mahomes and De'Andre Hopkins have made a quick connection. The Chiefs have owned the Broncos, winning 16 of the previous 17 games. But this a different Denver team. The Broncos are on the rise behind coach Sean Payton and rookie QB Bo Nix. They're 5-2 against the spread in their past seven games overall and 4-1 ATS in their past five games vs. Kansas City. The Chiefs are 10-3-1 ATS in their past 14 games overall.

CHIEFS: 26-20

San Francisco (4-4) at Tampa Bay (4-5)

Line: 49ers minus 5 1/2

The injury-depleted Bucs have to rebound on a short week after a disappointing finish Monday night when they nearly handed the Chiefs their first loss. Baker Mayfield and the offense keep putting up points even without Mike Evans and Chris Godwin. But the defense is allowing 27 points per game. The refreshed 49ers are coming off a bye and could see the return of Christian McCaffrey. San Francisco has used strong second halves to make deep playoff runs each of the past two seasons. With upcoming road games against Green Bay and Buffalo and tough home games against Seattle, Chicago, the Rams, the 49ers can't afford to slip up in this one.

Minnesota (6-2) at Jacksonville (2-7)

Line: Vikings minus 4 1/2

The Vikings kick off a stretch of three consecutive road games. They found a way to win last week despite three turnovers by Sam Darnold. The Jaguars had a chance to complete a stunning comeback win after trailing Philadelphia 22-0, but Trevor Lawrence's interception on a poor throw on first down from the 14 cost Jacksonville. The Jaguars have lost five games by five points or fewer.

VIKINGS: 26-23

Tennessee (2-6) at Los Angeles Chargers (5-3)

Line: Chargers minus 7 1/2

The Chargers have won consecutive games by at least 17 points and start a stretch of three straight home games. The passing game has opened up behind Justin Herbert and J.K. Dobbins is third in the AFC in yards rushing with 620. Maybe Will Levis can return and spark the Titans, who are already looking ahead to next year.

CHARGERS: 24-13

Philadelphia (6-2) at Dallas (3-5)

Line: Eagles minus 7 1/2

No Dak Prescott means no chance for Dallas. The Cowboys were already in trouble before Prescott sustained a hamstring injury that will force him to miss multiple games. Jalen Hurts is back to playing like the 2022 MVP runner-up and the Eagles are rolling with four straight wins. Saquon Barkley has been a major addition for Philadelphia, which has the No. 3 defense in the league.

EAGLES: 30-16

New York Jets (3-6) at Arizona (5-4)

Line: Cardinals minus 1

Aaron Rodgers, Davante Adams and Garrett Wilson showed what they can do together last week. Now, the Jets have to stack wins to have any chance of climbing into the playoff race. The Cardinals are surprise leaders in the NFC West and have already surpassed their win total in each of the past two seasons.

JETS: 23-20

Detroit (7-1) at Houston (6-3)

Line: Lions minus 3 1/2

Jared Goff is playing at an MVP level and the high-powered Lions have won six in a row. They added three-time Pro Bowl edge rusher Za'Darius Smith to bolster the defense and are primed to push for the NFC's No. 1 seed. The Texans need to protect C.J. Stroud better or they won't go anywhere in January. Relying on Joe Mixon running the ball will help.

LIONS: 24-22

Miami (2-6) at Los Angeles Rams (4-4)

Line: Rams minus 1

After an impressive road win, the Rams find themselves slight favorites at home vs. a two-win team. It's a strange line. Clearly, oddsmakers are giving the Dolphins a ton of respect. Tua Tagovailoa is 0-2 since returning from a concussion but has played superb. He has completed 80.3% of his passes with three touchdowns and no interceptions. With Cooper Kupp and Puka Nacua back from injuries, Matthew Stafford and L.A.'s offense is on track. The Rams have won three in a row.