San Francisco 49ers at Los Angeles Rams odds, expert picks, how to watch: Winless LA is a big home underdog

Of all the 0-2 teams in the NFL to start the season, the Los Angeles Rams might be facing the most desperate situation going into Week 3. Not only are they coming off a 31-point loss to Arizona, but now they have to play one of the best teams in the league and a divisional rival — the San Francisco 49ers. They do so without their top two wide receivers (Puka Nacua and Cooper Kupp) due to injury. Given that situation, it is probably not much of a surprise that they are a staggering touchdown underdog at home.

Coach Sean McVay and the Rams are going to have their work cut out for them against the 49ers with Kupp and Nacua both out.

The 49ers have their own share of injury problems: no Christian McCaffrey, Deebo Samuel or George Kittle. But they still have Brandon Aiyuk and an emerging star in running back Jordan Mason to carry the ball. Mason has been one of the biggest surprise stars of the season filling in for McCaffrey, already accounting for 247 yards on the ground and reaching the 100-yard mark in each of his first two starts.

The Rams defense is still trying to find its footing with a lot of new faces coming in this season while also dealing with the retirement of future Hall of Famer Aaron Donald.

The 49ers should still be able to get their points with the players in the lineup. The question is going to be whether or not Matthew Stafford can do enough with Tyler Johnson and Demarcus Robinson as his top two wide receivers to keep up with them.

All odds from BetMGM . Looking for NFL tickets? Find them here .