The Latest: Trump tests Congress with his controversial Cabinet picks

President-elect Donald Trump and Republicans say they have a mandate to govern . But an uneasy question is emerging: Will there be any room for dissent in the U.S. Congress?

Even before taking office, Trump is challenging the Senate , in particular, to dare defy him over the nominations of Matt Gaetz , Robert F. Kennedy Jr. and other controversial choices for his Cabinet and administration positions .

Here's the latest:

House Democratic leader Hakeem Jeffries questions Trump's Cabinet picks

House Democratic leader Hakeem Jeffries says Donald Trump promised on the campaign trail that America would have the best administration possible, but his nominees so far raise the question of whether the president-elect is fulfilling that promise.

Speaking to reporters Friday, Jeffries particularly singled out Trump's choice of anti-vaccine activist Robert F. Kennedy Jr. to lead the Department of Health and Human Services.

"Is Robert F. Kennedy Jr., by way of example, the best America has to offer? Will he and others give us the best opportunity to make a difference in the lives of the American people?"

He says the answer is clear.

Transgender-rights advocates say the election of Trump and his allies marks a major setback

Election victories for Donald Trump and other candidates whose campaigns demeaned transgender people reinforced a widespread backlash against trans rights. For America's LGBTQ+-rights movement, it adds up to one of the most sustained setbacks in its history.

For transgender Americans, it's personal: There is palpable fear of potential Trump administration steps to further marginalize them. But there's also a spirit of resilience — a determination to persevere in seeking acceptance and understanding.

"I just went through an election where I couldn't watch a sports event on TV without seeing a commercial where trans people were portrayed as monsters," said Jennifer Finney Boylan, a transgender author who teaches at Barnard College in New York.

Anti-trans momentum has been growing for several years, with Republican-governed states enacting dozens of laws restricting trans people's options for medical care, sports participation and public restroom access.

Voters held divided views on Robert F. Kennedy, Jr.

That's according to AP VoteCast, a survey of more than 120,000 voters nationwide. About 4 in 10 voters had a very or somewhat favorable opinion of Kennedy, and roughly 4 in 10 had a very or somewhat unfavorable view. Slightly more than 1 in 10 did not know enough about Kennedy to have an opinion.

Kennedy's anti-vaccine stance may be at odds with many voters' interests, if he's confirmed to lead the Health and Human Services Department. About half of voters said they wanted the government to be "more involved" in ensuring children are vaccinated for childhood diseases. About one-quarter said the government's current involvement is "about right," and only about 2 in 10 wanted the government less involved. Roughly 3 in 10 parents of children under 18 years old want the government less involved, compared to about 2 in 10 voters without children under 18.

About 6 in 10 voters said they wanted the government more involved in ensuring that Americans have health care coverage, and a similar share said they wanted the government to take a bigger role in forgiving medical debt. About three-quarters wanted the government more involved in lowering the cost of prescription drugs. In an election where pocketbook concerns were a primary focus, more than half of voters said they were "very concerned" about their health care costs.

WHO says global vaccine efforts have saved an estimated 154 million lives

In a report released in April, the U.N.'s World Health Organization said global immunization efforts have saved an estimated 154 million lives over the past half-century, roughly equivalent to six lives every minute of every year. More than 101 million lives were those of children.

Asked in Geneva on Friday about the nomination of anti-vaccine activist Robert F. Kennedy Jr. to lead the Department of Health and Human Services, WHO spokesperson Dr. Margaret Harris told reporters it's up to member countries — the U.S. is one of the biggest funders and sources of technical support to the U.N. agency — to decide who they appoint.

She also said vaccines were "absolutely critical" to good health outcomes.

"Vaccines are the reason so many more of us have survived to adulthood than we ever did before," said Harris. "Vaccine-preventable diseases have disappeared in the communities ... where vaccination has been widely available and has been widely taken up."

Trump is already testing Congress and daring Republicans to oppose him

After a resounding election victory , delivering what President-elect Donald Trump and Republicans said is a mandate to govern , an uneasy political question is emerging: Will there be any room for dissent in the U.S. Congress?

Trump is laying down a gauntlet even before taking office challenging the Senate , in particular, to dare defy him over the nominations of Matt Gaetz , Robert F. Kennedy Jr. and other controversial choices for his Cabinet and administration positions .