New Orleans Saints at Kansas City Chiefs odds, expert picks, how to watch: Patrick Mahomes, Chiefs look to stay undefeated

Monday Night Football delivers a compelling early-season tilt when the unbeaten Kansas City Chiefs host the New Orleans Saints . Injuries are piling up for the Kansas City offense as quarterback Patrick Mahomes navigates a rotating lineup around him. Kansas City is a huge home favorite despite its offensive uncertainty.

Kansas City leading receiver Rashee Rice is the latest standout sidelined with injury. Running back Isiah Pacheco remains out as well, making tight end Travis Kelce the focal point of the Chiefs' offense. Mahomes and Kelce shook off a slow start to 2024 by connecting a season-high seven times for 89 yards in Week 4's win over the Chargers .

An unsung New Orleans defense that is sixth in points allowed (17.5 per game) and seventh in rushing yards allowed per game (96.5) hopes to stall Mahomes and a rotating Kansas City backfield. Kareem Hunt could see a heavy workload following a solid season debut in Week 4 for the Chiefs.

Optimism was high in New Orleans, but a high-scoring 2-0 start sputtered with tight back-to-back losses. New Orleans still owns the NFL 's highest-scoring offense despite scoring only 36 of the team's 127 points in the past two weeks. Explosive plays from quarterback Derek Carr punctuated the offense early, but the Saints haven't generated a passing play longer than 29 yards over the last two games. The offensive line and key weapons Alvin Kamara and Taysom Hill are also beat up with injuries. Hill is out with a rib injury, although Kamara is expected to play.

To beat a sturdy Chiefs defense ranked No. 7 in points allowed (18 per game), diversifying the offense is paramount for New Orleans. Kamara and receivers Chris Olave and Rashid Shaheed make up 70 percent of Carr's targets. The Saints need additional options for Carr to maintain an elite offense.

All odds from BetMGM . Looking for NFL tickets? Find them here .